23-year-old Amélie is lonely. After an isolating childhood, she moves to Paris and becomes a waitress at the Café des Deux Moulins, a bar restaurant filled with a colourful cast of diners and employees.
One night, Amélie happens across a box of treasures hidden in her apartment, left by a little boy in the Fifties, that changes the course of her life. Henceforth, she dedicates herself to giving back to her community, tracking down the owner of these keepsakes, consoling a widowed neighbour and befriending a reclusive artist.
When completing these good deeds, she crosses paths with Nino, a photobooth collagist who shares her oddball sensibilities. She quickly falls in love with him.